Effects of etomidate, propofol and thiopental anaesthesia on arteriolar tone in the rat diaphragm.

Effects of i.v. anaesthetic agents on the chemotaxis of eosinophils in vitro.

Polymorphonuclear eosinophilic leucocytes (PME) participate in wound healing processes, the inflammatory response, bronchial asthma, allergies and defence against invading parasites. We have examined the effects of thiopental, methohexital, propofol, etomidate and ketamine on PME chemotaxis in vitro. PME were isolated from venous blood samples of 10 healthy volunteers using multi-stage Percoll ...

I.v. anaesthesia and EEG burst suppression in rats: bolus injections and closed-loop infusions.

We describe a system for monitoring and controlling i.v. anaesthesia in rats using burst suppression ratio (BSR) detection in the extradural EEG. After bolus injection, peak BSR values of 95% were achieved with propofol 8 mg kg-1, etomidate 3.5 mg kg-1 and alphaxalone 4.5 mg kg-1. Thiopental 32 mg kg-1 produced a peak BSR of 70% (larger doses were not tolerated). Recovery was fastest with propo...

Changes in haemodynamic variables with thiopentone, methohexitone, propofol and etomidate.

Comparison of the Haemodynamic Effects of Three Different Methods at the Induction of Anaesthesia.

OBJECTIVE Haemodynamic variations are inevitable during induction of anaesthetic drugs. The present study investigates the haemodynamic variations of three different drugs (thiopental, propofol, and etomidate) used for induction of general anaesthesia together with fentanyl. METHODS In a randomized, double-blind study, 45 patients were assigned to one of three groups (n=15 each). Fentanyl 1 μ...

Effect of thiopentone, etomidate and propofol on systemic vascular resistance during cardiopulmonary bypass.

We have studied the effect of thiopentone, etomidate and propofol on systemic vascular resistance (SVR) during cardiopulmonary bypass with constant pump flow in 30 patients undergoing elective coronary artery bypass surgery. SVR decreased to 78% of control values after thiopentone 4 mg kg-1, to 72% of control after etomidate 0.3 mg kg-1, and to 68% of control after propofol 2 mg kg-1; it return...